In vitro activities of the des-fluoro(6) Quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections.

نویسندگان

  • Ellie J C Goldstein
  • Diane M Citron
  • C Vreni Merriam
  • Yumi A Warren
  • Kerin L Tyrrell
  • Helen Fernandez
چکیده

BMS-284756, a new des-fluoro(6) quinolone, was very active against 240 aerobic and 180 anaerobic isolates from bite victims. It inhibited 403 of 420 (96%) isolates, including those of Moraxella spp., CDC group EF-4, and Eikenella corrodens at < or = 2 microg/ml and those of all Pasteurella spp. and Bergeyella zoohelcum at < or = 0.015 microg/ml. Fusobacterium russii and 6 of 11 Fusobacterium nucleatum isolates of animal bite origin were resistant, but isolates of human bite origin were susceptible, which suggests that they were of a different subspecies.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 46 3  شماره 

صفحات  -

تاریخ انتشار 2002